/Using the mutation call and survival data for solid tumors in TCGA dataset, we compared the model metrics of a Cox model and our FCN (Table 2). In most cancer types, there was limited difference between a Cox model and an FCN, suggesting the relationship likely is monotonic (or in some cases simply no relationship). However, in skin cutaneous melanoma (SKCM), the FCN displayed a noticeably better log likelihood and C-index. SKCM is a cancer type where immunotherapy is recommended and where TMB has been suggested as predictive biomarker (27, 28). Looking at some of the model fits, we see tumor types where the FCN predicted a perfectly linear relationship and followed the Cox predictions, cases where the FCN has slight deviations from the Cox predictions, and then SKCM where the FCN predicts a strong concave up relationship (Fig. 4).