/To clarify whether the broad-scale cyclic patterns of gene expression across the estrous cycle we identified in WT above were intact in Cnih3 KO mice, we Z-scored the KO expression levels of the same genes and overlaid them into the WT clustering space to compare their cyclic expression to WT. While many clustering patterns seemed to be generally retained—if sometimes with larger gene-set level variance in KO—there were notable discrepancies between WT and KO cycling patterns for clusters 1 and 3, two clusters defined by genes with peak expression in proestrus.