/Here, we identified 28 differential expression microRNAs (16 upregulated and 12 downregulated miRNAs, Fig S2C and Table S2-3) in the HH lines compared to CC. A total of 487 mRNAs were predicted as potential targets (table S8). We performed pathway enrichment analysis of these target genes to identify the biological functions of DEMs. The KEGG results revealed the enriched pathways involved in nuclear receptors, NK cell-mediated cytotoxicity, TNF signaling, p53 signaling, apoptosis, MAPK signaling, serotonergic synapse, and AGE-RAGE signaling in diabetic patients complications (table S9).