/To further investigate the origin of elevated EMT-related signature scores in bulk tumor specimens, we analyzed their signature scores and individual signature gene expression levels in eight scRNA-seq datasets derived from CRC, BRCA, glioblastoma, and Head and Neck squamous cell carcinoma (HNSC) samples (see Methods). After analyzing the impact of the macroenvironment on EMT-related signature scores in the previous sections, we analyzed the impact of cell type-specific expression profiles in the TME.